ncRNA name | MALAT1 |
ncRNA Category | lncRNA |
ID | 378938 |
Ensembl | ENSG00000251562 |
Synonyms | HCN, LINC00047, MALAT-1, NCRNA00047, NEAT2, PRO1073, mascRNA |
Disease name | uveal melanoma (UM) |
Species | Homo sapiens |
Tissues/Cell_line | UM samples and paired normal tissues; UM cell lines MUM-2C, OCM-1A, MUM-2B and C918; melanocyte cell line D78 |
Methods | qPCR, Western blot, MTT assay, colony information asssay, transwell assay |
Expression pattern | up-regulated |
Functional description | Knockdown of MALAT1 suppressed uveal melanoma cell proliferation, colony information, invasion and migration. Moreover, we showed that knockdown of MALAT1 promoted miR-140 expression and suppressed Slug and ADAM10 expression in the MUM-2C cell. |
PubMed ID | 27725873 |
Year | 2016 |
Title | Long noncoding RNA MALAT1 promotes uveal melanoma cell growth and invasion by silencing of miR-140. |
Drug-related ncRNA | NO |
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